The CAR that Adenovirus demands once inside our body.

Intro– In the deep forests of Guangdong, the patriarch Coronavirus was immersed in deep penance. His elephant trunk size spikes have turned silver grey from age and worries about the future of his tribe. His community, the tribe of the bat coronaviruses is in deep trouble. Bat was their natural home. For Billion of years they have stayed inside bats peacefully. Now this yesterday born biped-earth-walker has started destroying bat population slowly but steadily. Few centuries more, there will be no more bats and no more bat coronaviruses.

Sometimes around four centuries after the great flood of Gun-Yu, he got his revelation , a wisdom, that if successful, he can redeem his progeny from the impending doom towards oblivion. He was blessed with a novel spike. a spike like of that has never been seen earlier. This new spike is an exact fit into the locks that guard the lung cells of the biped human beings. With this new contraptions in hand, the bat Coronaviruses can safely leave their old habitat and colonise the lungs of a new host called human being. A new horizon, a new life. And then…]

Almost all of our Coronavirus Vaccines ( Except the Covaxin) target the spike protein of the virus. Spike protein is the key, by which the Covid-19 germ opens the door of our Lung cells and enters. Any vaccine that will block the spike will essentially stop the intrusion. So we have prepared a copy of the spike protein in our laboratory. But then how do we deliver it inside the human bodies ?

One of the methods is booking a special courier capable of entering human cells. It takes a thief to catch a thief. So it is another virus. Adenovirus is booked for delivery of the consignment against the Coronavirus. Initially we help them enter into our body. Once inside the human body, these viruses can easily intrude into a cell. They have the biometrics to enter even into the nucleus where the deepest secrets of life are stored.

Adenoviruses are seasoned couriers. We have been using them earlier to deliver deadly drugs deep into the core of Cancerous tumours.

why the Adenoviruses agrees is a different matter, but they do not come cheap.

Once inside our body, the virus starts booking the CAR to visit its lady love- our platelets. They have a fancy for the tiny little miss platelets. Platelets in our body have the important duty to keep our blood fluid. But once the affair between adenovirus virus and lady platelet starts, the girl absconds from duty. Platelet count can fall and blood can clot here and there.

https://pubmed.ncbi.nlm.nih.gov/21962080/

Human platelets express CAR: Coxsackie Adenovirus Receptor.

Sometimes small clots can occur in very sensitive parts of our body like inside our brain or behind our eyes. They are rare though, but sometimes they can be life threatening. They are called by the acronym CVST.

CVST- Cerebral Venous Sinus Thrombosis

Symptoms- Severe headache, blurring of vision.

Timing- can occur between 5-24 days following vaccination. 

Age- happens more in younger age group.

If you get these symptoms after say 2 months, especially among elderly people, most likely it can have other reasons.

Treatment- easy if reported early. But once any thing is damaged inside brain or eye, the defect will be permanent.

NB-

• Only Astrazeneca, Jhonson & Jhonson, Sputnik V of Gamaleya use adenovirus as the vector to deliver spike protein.
• Each intramuscularly injected dose of Covishield vaccine contains 5 × 10^10 viral particles
• Adenoviruses can utilize CAR and other receptors to infect platelets.
• CAR– Coxsackie Adenovirus Receptor.
• There is temporary suspension of the vaccine (Oxford/AstraZeneca) in various Eu­ropean countries and the Ad26.COV2 vaccine (Janssen/Johnson&Johnson) in the United States which has been lifted.
• It is marked by unusual thrombotic events associated with thrombocytopenia.
• Did we know this earlier ?
•   Yes, animal experiment earlier has pointed out this. They are ignored, because the earlier patients are terminal cancer cases. But this time the animal trial has been bypassed to speed up vaccine production.